Hot Selling Ophthalmic Solution Container Production and Sealing Process/Eye Drop Bottle Forming, Filling, and Capping System

After-sales Service: Field Installation, Commissioning and Training
Warranty: 1 Year
Type: Volumetric Filling Machine

Product Description

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Basic Info.

Automatic GradeAutomatic
Material TypeGranular
Filling Valve HeadMulti-Head
Feed Cylinder StructureMulti-Room Feeding
Dosing DeviceCapacity Cup
Filling PrinciplePressure
Packaging Container Lifting StructurePneumatic Lifting
StructureRotary
PackagingBox
Packaging MaterialPlastic
DeflasherInternal Punching
Power Source3p/AC380V
Installed Power42kw
Machine StructureDark Side White Side Unseperation
Packing MaterialsPE/PP
Capacity (Bottle Per Hour)3000 PCS/Hour(1ml); 1500 PCS/Hour(10ml)
Filling Accuracy1.5% (Based on 5ml)
Manufacturing StandardcGMP
OriginChina
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Packaging & Delivery

Package Size200.00cm * 150.00cm * 150.00cm
Package Gross Weight2000.000kg
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Product Description

Hot Selling Ophthalmic Solution Container Production and Sealing Process / Eye Drop Bottle Forming, Filling, and Capping System

The BFS is a dedicated state of the art system, enabling primary packaging of bulk pharmaceutical solutions into plastic containers of polypropylene or high density polyethylene or low density PE, using a Blow-Fill-Seal (BFS) technology.

The BFS processes are performed automatically in a single machine under a controlled environment (sterile filtered air-shower):

  • Extrusion of plastic granulate into a parison at high temperatures
  • Blow-moulding of parison into a container with sterile-filtered air
  • Filling of sterile-filtered solution
  • Hermetic sealing of filled container
BFS System 1
BFS System 2

This filling unit assembly is composed of filling nozzles, the manifold with filling valves, the assembly for sterile air shower around the nozzles, the guide bars and the drive. In most cases, it is possible to provide a special cylinder drive for shifting the nozzles up and down. Such drive is compact and is particularly suitable for clean environments. The absence of hydraulic cylinders offers a safe and clean assembly right above the filling nozzles.

Filling Nozzles Detail
Filling Unit

Our Advantages

  • The design, manufacture, and assembly of the BFS machine meet the requirements of the new GMP standards.
  • Advanced equipment with stable and reliable performance.
  • Applicable specification: 0.2ml-1000ml plastic bottles.
  • Production Capacity: 1000-18000BPH (Customized).
  • Filling accuracy: ≤ ±1%.
  • Integrated bottle making, filling, and capping, reducing clean workshop area and saving energy.
  • Servo motor-driven extruder reduces thermal stress and accurately controls preform size.
  • Real-time feedback control for every cycle.
Advantage 1
Advantage 2
Advantage 3
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Product Parameters

ProjectParameters of BFS Machine
1Size(L×W×H)3500*1400*2800mm
2Weight4.5T
3DeflasherInternal punching
4Power Source3P/AC380V
5Installed Power42Kw
6Power Rating30Kw
7Machine StructureDark side white side unseparation
8Packing MaterialsPE/PP
9Specification1ml-50ml
11Capacity3000 pcs/h(1ml); 1500 pcs/h(10ml)
12Filling Accuracy±1.5% (based on 5ml)
13Manufacturing StandardcGMP
14Electrical StandardIEC 60204-1; GB/T 4728
15Compress Airno oil, no water @ 8bar, 200NL/min
16Cooling Water8-12ºC (pure water) @ 4bar, 2m³/h
17Pure Steam125ºC @ 2bar, 25kg/h
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Process & Quality

Workflow 1
Workflow 2
Solution View
Quality Standards
Equipment View Machine Detail Certifications Project Case Global Support

Frequently Asked Questions

1. What is BFS (Blow-Fill-Seal) technology?

BFS technology is an advanced manufacturing process where the container is formed, filled, and sealed in one continuous, automated system under sterile conditions. This minimizes human intervention and contamination risks.

2. What volume sizes can the machine produce?

The machine is highly versatile, supporting container sizes ranging from 0.2ml up to 1000ml, with specific models optimized for the 1ml-50ml range commonly used for ophthalmic solutions.

3. Does the equipment meet international standards?

Yes, the machine design and manufacturing process strictly adhere to cGMP standards and electrical safety standards such as IEC 60204-1.

4. What materials are used for the plastic containers?

The system is compatible with medical-grade plastic granulates including Polypropylene (PP), High-Density Polyethylene (HDPE), and Low-Density Polyethylene (LDPE).

5. What is the typical production capacity?

Production capacity is customizable based on user requirements, ranging from 1,000 to 18,000 bottles per hour. For 1ml eye drop bottles, the standard capacity is approximately 3,000 pieces per hour.

6. What are the utility requirements for operation?

The machine requires a 3P/AC380V power source, compressed air at 8bar, cooling water at 8-12ºC, and pure steam at 125ºC for sterilization.

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